The Wenatchee River is a river in Washington originating at Lake Wenatchee and flowing southeast until it meets the Columbia River immediately north of Wenatchee, Washington. On its way it passes the towns of Leavenworth, Peshastin, Dryden, Cashmere, and Monitor.
Historically the dividing line between Okanogan County and Kittitas County, the river has been in the center of Chelan County since the county's formation around 1899.