Walworth Road is a road in the London Borough of Southwark, running between Elephant and Castle and Camberwell Road (which it becomes at Burgess Park).

It runs through Walworth and is the major shopping street for that area. The East Street Market is especially busy on Saturdays and Sundays.

Other attractions include the Cuming Museum, Newington Reference Library and John Smith House, a former Labour Party headquarters which is now used by the local education authority.

Charles Babbage, the Victorian mathematician and computer pioneer, was probably born at 44 Crosby Row, Walworth Road on 26 December 1792. A commemorative blue plaque is displayed on the Sexual Health Clinic at the junction of Larcom Street and Walworth Road.

The Walworth Road is designated the A215.