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A spacer is generally something used to create a space between two objects, often to properly position them.
There are also a number of specialised usages for the term.
Asthma spacers are used to ensure proper delivery of inhaled asthma medication.
Spacers, the first humans to emigrate to space in Isaac Asimov's Robot Series, also used in certain other sci-fi franchises to designate a being who resides primarily aboard ships and stations in space
in space opera, and science fiction and roleplaying games in general, the word is often used to refer to humans in general or a specific caste of humans who live in outer space, or (by analogy with "sailor") serve as the crew of spaceships.
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