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The Serenity Prayer, a famous prayer written by Reinhold Niebuhr.

Princess Serenity, main character from the manga and anime Sailor Moon.

Serenity Wheeler (Shizuka Kawai), a character from Yu-Gi-Oh!.

''Serenity'' (manga), a Christian-based manga series.

Serenity (porn star), an adult video actress.

''Serenity'' (Dark Lunacy album), an album of Dark Lunacy band.

''Serenity'' (Culture Beat album), an album by Culture Beat.

Crystal Serenity, a cruise ship.

''Serenity'' (film), a film that follows the series.

''Serenity'' (Firefly vessel), the Firefly-class spaceship from the series.

"Serenity" (Firefly episode), the pilot episode of the series.

, a 2005 comic book miniseries set between the series and the film.

''Serenity'' (soundtrack), the soundtrack to the film.

''Serenity'' (role-playing game), a role-playing game by Margaret Weis Productions, Ltd.

The Battle of Serenity Valley, a key event in the history of the series from the episode of the same name.