Rancho Bernardo is a neighborhood of the city of San Diego, California, located in the county of the latter's same name. It is geographically located about 20 miles north-north-east of downtown San Diego, immediately northwest of the city of Poway and south of Escondido.

Rancho Bernardo, or popularly known as RB, was born in 1789 with a land grant from the king of Spain as La Cañada de San Bernardo (or "The Gorge of Saint Bernard"). As the early name implies, the topography of RB consists of canyons and rolling hills. At the beginning of RB's history (circa 1800) the population consisted of a volatile combination of indigenous Native Americans and ranchers.

The early 1960s saw RB's evolution into its present state and nomenclature when a real estate company known as “Rancho Bernardo, Inc.” obtained incorporation with the approval of the AVCO Community Developers. This was the beginning of Rancho Bernardo as it is known today.