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Octopamine is a biogenic amine which is closely related to noradrenaline.
Octopamine was first discovered by Italian scientist Vittorio Erspamer in 1948 in the salivary glands of the octopus and has since been found to act as neurotransmitter, neurohormone and neuromodulator in invertebrates.
Octopamine also replaces norepinephrine in sympathetic neurons with chronic use of Monoamine Oxidase Inhibitors. It is responsible for the common side-effect profile of orthostatic hypotension with these agents.
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