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Million instructions per second, a measure of microprocessor speed

MIPS architecture, Microprocessor without Interlocked Pipeline Stages, a RISC microprocessor architecture

MIPS Technologies, formerly MIPS Computer Systems, developer of the MIPS architecture

MIPS (character), a yellow rabbit in the game Super Mario 64

Material input per unit of service, an economic efficiency indicator

Munich Information Center for Protein Sequences, a genomics research center in Germany