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Locus (genetics), the position of a gene (or other significant sequence) on a chromosome.

Locus (mathematics), the set of points satisfying a particular condition, often forming a curve of some sort.

Locus (phonetics), the hypothetical starting point of the formant transitions that characterise plosive consonants acoustically.

In the classics, literature or theology, locus (or locus classicus) marks the first appearance of a phrase or the definitive passage that is authoritative for an idea.

Locus is also the title of a magazine carrying news about science fiction.

Locus is also a Baltimore-based Arts Magazine.

Locus Computing Corporation developed the LOCUS clustering operating system, as well as the Merge 8086 virtual machine implementation.

LOCUS Operating System started as a clustering OS research project at UCLA, and was then developed into a commercial product by Locus Computing Corporation in the 1980s.

The method of loci is one of the major mnemonic systems.

Locus is a racing computer game set in the future.