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John Locke, an English Enlightenment philosopher.

John Locke (musician), former member of the jazz-hard rock band, Spirit.

John Locke (Canadian politician), a Nova Scotia Senator from 1867 - 1873.

Joseph Locke, English civil engineer of the 19th century, associated with railways.

Alain LeRoy Locke was an African American educator, writer, and philosopher.

Matthew Locke (composer), an English Baroque composer.

Keith Locke is a New Zealand Member of Parliament for the Green Party of Aotearoa New Zealand.

Sondra Locke is an American actor.

William John Locke was an English author.

It is also used as a spelling of the Cantonese pronunciation of the Chinese name of US politician Gary Locke.

Locke The Thief is a California born and raised MC.

Locke, California, a town in Sacramento County, California.

Locke Township, Michigan, is a township located in Ingham County, Michigan.

Locke, New York, a town in Cayuga County, New York.

Mount Locke, in the Davis Mountains of West Texas, is home to the University of Texas' McDonald Observatory.

The pseudonym Locke is used by the character Peter Wiggin in novels by Orson Scott Card, in honor of the philosopher.

John Locke is a character in the television series LOST.

Locke Cole is a character in the video game Final Fantasy VI.

Locke is the main character of the manga Locke the Superman.

Locke the Echidna is a Sonic the Hedgehog character, a member of the Brotherhood of Guardians.