The High School of Art and Design is a Career and Technical Education high school located at 1075 Second Avenue, between 56th and 57th Streets in Manhattan, New York City, New York.

It is operated by the New York City Department of Education. A venerable school that was founded in 1936 as the School of Industrial Art, it moved to its present location in the center of the city's design district in September 1960, and offers a traditional academic education, augmented with advanced courses in the professional arts. 90% of its graduates continue on in post-secondary education.

Students at Art and Design receive two periods of art instruction per day, choosing from among four art majors: cartooning and animation, architecture, illustration (which includes fashion illustration and medical illustration), and new media (which includes digital photography and filmmaking). In addition to contemporary methods they are taught some "old-fashioned" basics, such as drawing and darkroom skills. Applicants must take an entrance exam and present a portfolio to be accepted.

Art and Design's Kenny Gallery, named for the school's founding principal John B. Kenny, hosts monthly art exhibits of student work, in addition to the annual display of Region 9's best student work and the annual faculty art show and sale. The ground floor art gallery faces Second Avenue and is open to the public. The school has a full gym and weight room, a library and a fully-equipped black box theater where the Roundabout Theater Company works with students on drama. The theater was donated by the Friends of Art and Design (FAD), a 10-year-old old community-based volunteer organization that has been exceptionally supportive of the school.