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Handle (grip), a device, attached to an object, that is gripped to move or use the object

Handle, a kind of smart pointer, a reference to a position in computer memory

Handle (mathematics), a term used in topology

Handle, the friction and flexibility of sheets of material as measured by Handle-o-Meter

Handle, a pseudonym used in Citizens' band radio

Handle or screen name (computing), a pseudonym used within an online system

A handle is a 1.75 liter (approx. half gallon) bottle of a distilled beverage because bottles of that size often have a handle

Handle, the total amount bet at a performance at a venue which offers parimutuel betting, such as a horse racing track, dog racing track, or jai alai fronton