Navigation
  • Home
  • Recent
  • Most Active
  • Popular
  • Credits
  • RSS
  •  
      Help
  • How to Edit
  • Help



  • [Edit]




    Genentech, Inc. (), a composite of Genetic Engineering Technology, Inc., is a leading biotechnology corporation, which was founded in 1976 by Robert A. Swanson, a venture capitalist, and biochemist Dr. Herbert W. Boyer. It is considered to have founded the biotechnology industry.

    One of its founders, Dr. Herbert W. Boyer, is considered to be one of the pioneers in the field of recombinant DNA technology (the company's ticker symbol reflects Boyer's contribution to the field). Boyer worked with Arthur Riggs and Keiichi Itakura from the Beckman Research Institute, and the group became the first to successfully express a human gene in bacteria when they produced the hormone somatostatin in 1977. David Goeddel and Dennis Kleid were then added to the group, and contributed to its success with insulin in 1978.

    Currently (2006), Genentech employs more than 10,000 people and Arthur D. Levinson is the Chairman and CEO. The Swiss pharmaceutical conglomerate Hoffmann-La Roche owns the majority of Genentech shares *.


        Genentech
            Product Timeline
            Awards and Recognitions
            Facility locations
            Disputes
            Research
    Company NameGenentech, Inc.
    Company LogoImage:Genentechlogo.gif
    Company TypePublic company
    Public]] (nyse:[http://qu...DNA%60&selected=DNA%60 DNA)
    Company SloganIn business for life
    Foundation1976
    LocationSouth San Francisco, California, USA
    Key PeopleArthur D. Levinson, Chairman & CEO
    Susan ...
    IndustryBiotechnology
    ProductsInsulin, Protropin, Activase, Actimmune, Nutr...
    Revenueprofit$6.633 Billion United States dollar
    Net Incomeprofit$1.278 Billion United States dollar
    Num Employees9,500 (2005)

    top

    Product Timeline
      1982 - Human Insulin - First ever approved genetically engineered human therapeutic
      1987 - Activase® (recombinant tissue plasminogen activator)- To dissolve blood clots in patients with acute myocardial infarction. Also used to treat non-hemmoragic stroke.
      1997 - Rituxan® (rituximab)- Treatment for specific kinds of non-Hodgkins lymphomas.
      1998 - Herceptin® (trastuzumab) - Treatment for metastatic breast cancer patients with tumors that overexpress the HER2 gene. Recently approved for adjuvant therapy for breast cancer.
      2003 - Xolair® (omalizumab) - Subcutaneous injection for moderate to severe persistent asthma.
      2004 - Avastin® (bevacizumab) - Anti-VEGF monoclonal antibody for the treatment of metastatic cancer of the colon or rectum.
      2004 - Tarceva® (erlotinib) - Treatment for patients with locally advanced or metastatic non-small cell lung cancer, and pancreatic cancer.
      2006 - Lucentis® (ranibizumab injection) - The U.S. Food and Drug Administration (FDA) has approved LUCENTIS(TM) (ranibizumab injection) for the treatment of neovascular (wet) age-related macular degeneration (AMD). The FDA approved LUCENTIS after a Priority Review (six-month). Genentech started shipping product on June 30th, 2006.

    top

    Awards and Recognitions
      Fortune Magazine has named Genentech number one on its 2006 list of the "100 Best Companies To Work For." This is the first number one ranking for the company, which has been named to the list for eight consecutive years. The ranking is based on anonymous employee responses to a survey as well as an evaluation of the company's policies and culture.

    top

    Facility locations
    Genentech's corporate headquarters is at South San Francisco, CA, with additional manufacturing facilities in Vacaville, California and Porrino, Spain. In June 2005, Genentech purchased Biogen Idec's manufacturing facility in Oceanside, California. On March 17, 2006, Genentech announced its decision to construct a new manufacturing facility in Hillsboro, Oregon which is expected to be operational by 2010.

    top

    Disputes
    In 1999, Genentech has agreed to pay the University of California, San Francisco, $200 million to settle a nine year old patent dispute. In 1990, UCSF sued Genentech for $400 million in compensation for alleged theft of technology developed at the university and covered by a 1982 patent. Genentech claimed that they developed Protropin, a growth hormone, independently of UCSF. A jury ruled that the university's patent was valid last July, but wasn't able to decide whether Protropin was based upon UCSF research or not. Protropin, a drug used to treat dwarfism, was Genentech's first marketed drug and its $2 billion in sales is has contributed greatly to Genentech's position as an industry leader. The settlement was to be divided as follows: $30 million to the University of California General Fund, $85 million to the three inventors and two collaborating scientists, $50 million towards a new teaching and research campus for UCSF, and $35 million to support university-wide research.

    top

    Research
    The company places a lot of importance on research in the basic sciences and to that end, it has on its rolls some of the best scientists of the contemporary era. Prominent ones include Senior VP Marc Tessier-Lavigne who discovered netrins and VP Vishva Dixit who is a leading authority on apoptosis.
     

    -->
    Search more:
     

       
    Source Privacy License Download Contact Us Atlas
    Scientus.org Dictionary (Yet Another Wiki) RC : 1.41
    MIT OpenCourseWare
    This article is licensed under the GNU Free Documentation License [copyleft]. It uses material from the Wikipedia article "Genentech". link