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Google Desktop Search, a software application for searching files stored on a local area network or hard disk

Global distribution system, computer systems for searching, reserving, and purchasing travel products

Geriatric Depression Scale, a simple, self-administered assessment of depression among the elderly

Global Dialing Scheme, a numbering plan for video and voice over IP networks

Georgetown Day School, a private school in Washington, DC

Gribskovbanens Driftsselskab, a Danish railway company (see Gribskovbanen)

Graphic Data System (see GDSII), a format for IC layout data.