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Dual Polarisation Interferometry (DPI) DPI is an analytical technique used to understand the real-time structure and behaviour of a wide range of molecular systems and interactions through quantitative measurement. DPI has been successful across a range of applications, including proteins, lipids, nucleic acids, lectins, surfactants, polymers, interfacial studies, surface characterisation and nanotechnology. DPI provides real-time, high-resolution measurements of molecular size, density and mass. Its measurements can be compared directly with complimentary techniques such as NMR, x-ray crystallography and neutron reflection, whilst also being capable of kinetic measurement at far higher sensitivity than first-generation biosensor technologies such as SPR or QCM, which offer only limited and ambiguous information. DPI utilises a sensing waveguide to measure quantitatively Refractive Index and Thickness in real time of chemistry taking place on a chip surface in a flow through system. As it is an analytical technique the quantitative measurements can be used ot infer structural information about the molecular intereactions taking place.
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