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David S. Lewis, Jr. (aerospace) (1917–2003), known for his engineering and business leadership at McDonnell Aircraft, McDonnell Douglas, and General Dynamics

David Kellogg Lewis (1941–2001), an American-born philosopher famous for his theory of modal realism and his love for Australia

David Lewis (musician), a singer-songwriter

David Lewis (politician) (1909–1981), a Russian-born Canadian lawyer and politician

David Lewis (producer) (1903–1987), Hollywood film producer and partner of film director James Whale

Dave Lewis, NHL head coach

David Lewis (actor), known for his role as Edward on General Hospital

Saint David Lewis, one of the Catholic Forty Martyrs of England and Wales

David Lewis (psychologist), an English author and psychologist

David Robert Lewis (writer & artist), a South African instrumental in the country's alternative counter-culture and the transition to democracy

David Lewis (striker), a Rand Revolt striker who was hanged for the murder of Rupert William Taylor on 17 November 1922

David Henry Lewis MD, DCNZM (1917–2002), navigator and adventurer

David John Lewis, Maryland politician

David Christopher Lewis, Born 19 October 1980, English Techincal Engineer

David Lewis (English merchant) (1823–1885), English merchant and philanthropist

David Lewis (reuters) journalist, mysteriously reporting from the DRC after David Robert Lewis called for peace in the country