When Philip led an attack on Byzantium in 340 BC, Alexander, aged 16, was left as regent of Macedonia. In 339 BC, Philip took a fifth wife, the Macedonian Cleopatra. As Alexander's mother, Olympias, was from Epirus (a land in the western part of the Greek peninsula and not part of Macedon), and Cleopatra was a true Macedonian, this led to a dispute over Alexander's legitimacy as heir to the throne. Attalus, the uncle of the bride, supposedly gave a toast during the wedding feast giving his wish for the wedding to result in a legitimate heir to the throne of Macedon; Alexander hurled his goblet at Attalus shouting "What am I, a bastard then?" Alexander's father apparently had drawn his sword and moved towards Alexander, but then had fallen in a drunken stupor. Alexander remarked "Here is the man planning on conquering from Greece to Asia, and he cannot even move from one table to another." Alexander, his mother, and sister (also named Cleopatra) then left Macedon in anger.

Eventually Philip reconciled with his son, and Alexander returned home; Olympias and Alexander's sister remained in Epirus. In 338 BC Alexander assisted his father at the decisive Battle of Chaeronea against the Greek city-states of Athens and Thebes, in which the cavalry wing led by Alexander annihilated the Sacred Band of Thebes, an elite corps regarded as invincible. After the battle, Phillip led a wild celebration, from which Alexander was notably absent (it is believed he was treating the wounded and burying the dead, both of his own troops and of the enemy). Philip was content to deprive Thebes of its dominion over Boeotia and leave a Macedonian garrison in the citadel. A few months later, to strengthen Macedon's control over the Greek city-states, the League of Corinth was formed.

In 336 BC, Philip was assassinated at the wedding of his daughter Cleopatra of Macedonia to King Alexander of Epirus. The assassin was supposedly a former lover of the king, the disgruntled young nobleman Pausanias of Orestis, who held a grudge against Philip because the king had ignored a complaint he had expressed. Philip's murder was once thought to have been planned with the knowledge and involvement of Alexander or Olympias. Another possible instigator could have been Darius III, the recently crowned King of Persia. After Philip's death, the army proclaimed Alexander, then aged 20, as the new king of Macedon. Greek cities like Athens and Thebes, which had been forced to pledge allegiance to Philip, saw in the new king an opportunity to retake their full independence. Alexander moved swiftly and Thebes, which had been most active against him, submitted when he appeared at its gates. The assembled Greeks at the Isthmus of Corinth, with the exception of the Spartans, elected him to the command against Persia, which had previously been bestowed upon his father.

The next year, (335 BC), Alexander felt free to engage the Thracians and the Illyrians in order to secure the Danube as the northern boundary of the Macedonian kingdom. While he was triumphantly campaigning north, the Thebans and Athenians rebelled once again. Alexander reacted immediately and while the other cities once again hesitated, Thebes decided this time to resist with the utmost vigor. The resistance was useless; in the end, the city was conquered with great bloodshed. The Thebans encountered an even harsher fate when their city was razed to the ground and its territory divided between the other Boeotian cities. Moreover, all of the city's citizens were sold into slavery; Alexander spared only the priests, the leaders of the pro-Macedonian party, and the descendants of Pindar, whose house was the only one left standing. The end of Thebes cowed Athens into submission and it readily accepted Alexander's demand for the exile of all the leaders of the anti-Macedonian party, Demosthenes first of all.

Alexander's army had crossed the Hellespont with about 42,000 soldiers—primarily Macedonians and Greeks, more southern city-states of Greece, but also including some Thracians, Paionians and Illyrians. After an initial victory against Persian forces at the Battle of Granicus, Alexander accepted the surrender of the Persian provincial capital and treasury of Sardis and proceeded down the Ionian coast. At Halicarnassus, Alexander successfully waged the first of many sieges, eventually forcing his opponents, the mercenary captain Memnon of Rhodes and the Persian satrap of Caria, Orontobates, to withdraw by sea. Alexander left Caria in the hands of Ada, who was ruler of Caria before being deposed by her brother Pixodarus. From Halicarnassus, Alexander proceeded into mountainous Lycia and the Pamphylian plain, asserting control over all coastal cities and denying them to his enemy. From Pamphylia onward, the coast held no major ports and so Alexander moved inland. At Termessus, Alexander humbled but did not storm the Pisidian city. At the ancient Phrygian capital of Gordium, Alexander "undid" the tangled Gordian Knot, a feat said to await the future "king of Asia." According to the most vivid story, Alexander proclaimed that it did not matter how the knot was undone, and he hacked it apart with his sword. Another version claims that he did not use the sword, but actually figured out how to undo the knot.



Alexander's army crossed the Cilician Gates, met and defeated the main Persian army under the command of Darius III at the Battle of Issus in 333 BC. Darius fled this battle in such a panic for his life that he left behind his wife, his two daughters, his mother Sisygambis, and much of his personal treasure. Proceeding down the Mediterranean coast, he took Tyre and Gaza after famous sieges (see Siege of Tyre). Alexander passed through Judea near Jerusalem but probably did not visit the city.

In 332 BC–331 BC, Alexander was welcomed as a liberator in Egypt and was pronounced the son of Zeus by Egyptian priests of the god Ammon at the Oracle of the god at the Siwa Oasis in the Libyan desert. Henceforth, Alexander referred to the god Zeus-Ammon as his true father, and subsequent currency featuring his head with ram horns was proof of this widespread belief. He founded Alexandria in Egypt, which would become the prosperous capital of the Ptolemaic dynasty after his death. Leaving Egypt, Alexander marched eastward into Assyria (now northern Iraq) and defeated Darius and a third Persian army at the Battle of Gaugamela. Darius was forced to flee the field after his charioteer was killed, and Alexander chased him as far as Arbela. While Darius fled over the mountains to Ecbatana (modern Hamadan), Alexander marched to Babylon.



From Babylon, Alexander went to Susa, one of the Achaemenid capitals, and captured its treasury. Sending the bulk of his army to Persepolis, the Persian capital, by the Royal Road, Alexander stormed and captured the Persian Gates (in the modern Zagros Mountains), then sprinted for Persepolis before its treasury could be looted. After several months Alexander allowed the troops to loot Persepolis. A fire broke out in the eastern palace of Xerxes and spread to the rest of the city. It was not known if it was a drunken accident or a deliberate act of revenge for the burning of the Athenian Acropolis during the Second Persian War. The Book of Arda Wiraz, a Zoroastrian work composed in the 3rd or 4th century AD, also speaks of archives containing "all the Avesta and Zand, written upon prepared cow-skins, and with gold ink" that were destroyed; but it must be said that this statement is often treated by scholars with a certain measure of skepticism, because it is generally thought that for many centuries the Avesta was transmitted mainly orally by the Magians.

He then set off in pursuit of Darius, who was kidnapped, and then murdered by followers of Bessus, his Bactrian satrap and kinsman. Bessus then declared himself Darius' successor as Artaxerxes V and retreated into Central Asia to launch a guerrilla campaign against Alexander. With the death of Darius, Alexander declared the war of vengeance over, and released his Greek and other allies from service in the League campaign (although he allowed those that wished to re-enlist as mercenaries in his imperial army).

His three-year campaign against first Bessus and then the satrap of Sogdiana, Spitamenes, took him through Media, Parthia, Aria, Drangiana, Arachosia, Bactria, and Scythia. In the process, he captured and refounded Herat and Maracanda. Moreover, he founded a series of new cities, all called Alexandria, including modern Kandahar in Afghanistan, and Alexandria Eschate ("The Furthest") in modern Tajikistan. In the end, both were betrayed by their men, Bessus in 329 BC and Spitamenes the year after.

After the death of Spitamenes and his marriage to Roxana (Roshanak in Bactrian) to cement his relations with his new Central Asian satrapies, in 326 BC Alexander was finally free to turn his attention to India. Alexander invited all the chieftains of the former satrapy of Gandhara, in the north of present-day Pakistan, to come to him and submit to his authority. Ambhi, ruler of Taxila, whose kingdom extended from the Indus to the Hydaspes (Jhelum), complied. But the chieftains of some hilly clans including the Aspasios and Assakenois sections of the Kambojas (classical names), known in Indian texts as Ashvayanas and Ashvakayanas (names referring to their equestrian nature), refused to submit.

Alexander personally took command of the shield-bearing guards, foot-companions, archers, Agrianians and horse-javelin-men and led them against the Kamboja clans—the Aspasios of Kunar/Alishang valleys, the Guraeans of the Guraeus (Panjkora) valley, and the Assakenois of the Swat and Buner valleys. Writes one modern historian: "They were brave people and it was hard work for Alexander to take their strongholds, of which Massaga and Aornus need special mention." A fierce contest ensued with the Aspasios in which Alexander himself was wounded in the shoulder by a dart but eventually the Aspasios lost the fight; 40,000 of them were enslaved. The Assakenois faced Alexander with an army of 30,000 cavalry, 38,000 infantry and 30 elephants. They had fought bravely and offered stubborn resistance to the invader in many of their strongholds like cities of Ora, Bazira and Massaga. The fort of Massaga could only be reduced after several days of bloody fighting in which Alexander himself was wounded seriously in the ankle. When the Chieftain of Massaga fell in the battle, the supreme command of the army went to his old mother Cleophis (q.v.) who also stood determined to defend her motherland to the last extremity. The example of Cleophis assuming the supreme command of the military also brought the entire women of the locality into the fighting. Alexander could only reduce Massaga by resorting to political strategem and actions of betrayal. According to Curtius: "Not only did Alexander slaughter the entire population of Massaga, but also did he reduce its buildings to rubbles." A similar manslaughter then followed at Ora, another stronghold of the Assakenois.

In the aftermath of general slaughter and arson committed by Alexander at Massaga and Ora, numerous Assakenian people fled to a high fortress called Aornos. Alexander followed them close behind their heels and captured the strategic hill-fort but only after the fourth day of a bloody fight. The story of Massaga was repeated at Aornos and a similar carnage on the tribal-people followed here too.

Writing on Alexander's campaign against the Assakenois, Victor Hanson comments: "After promising the surrounded Assacenis their lives upon capitulation, he executed all their soldiers who had surrendered. Their strongholds at Ora and Aornus were also similarly stormed. Garrisons were probably all slaughtered.”

Sisikottos, who had helped Alexander in this campaign, was made the governor of Aornos.

After reducing Aornos, Alexander crossed the Indus and fought and won an epic battle against Porus, a ruler of a region in the Punjab in the Battle of Hydaspes in 326 BC.

After the victory, Alexander was greatly impressed by Porus for his bravery in battle, and therefore made an alliance with him and appointed him as satrap of his own kingdom, even adding some land he did not own before. Alexander then named one of the two new cities that he founded, Bucephala, in honor of the horse who had brought him to India, who had died during the Battle of Hydaspes. Alexander continued on to conquer all the headwaters of the Indus River.

East of Porus' kingdom, near the Ganges River, was the powerful empire of Magadha ruled by the Nanda dynasty. Fearing the prospects of facing another powerful Indian army and exhausted by years of campaigning, his army mutinied at the Hyphasis River (the modern Beas River), refusing to march further east. This river thus marks the eastern-most extent of Alexander's conquests:

"As for the Macedonians, however, their struggle with Porus blunted their courage and stayed their further advance into India. For having had all they could do to repulse an enemy who mustered only twenty thousand infantry and two thousand horse, they violently opposed Alexander when he insisted on crossing the river Ganges also, the width of which, as they learned, was thirty-two furlongs, its depth a hundred fathoms, while its banks on the further side were covered with multitudes of men-at-arms and horsemen and elephants. For they were told that the kings of the Ganderites and Praesii were awaiting them with eighty thousand horsemen, two hundred thousand footmen, eight thousand chariots, and six thousand fighting elephants." Plutarch, Vita Alexandri, 62

On the afternoon of June 10–11, 323 BC, Alexander died of a mysterious illness in the palace of Nebuchadrezzar II of Babylon. He was just one month shy of attaining 33 years of age. Various theories have been proposed for the cause of his death which include poisoning by the sons of Antipater or others, sickness that followed a drinking party, or a relapse of the malaria he had contracted in 336 BC.

It is known that on May 29, Alexander participated in a banquet organized by his friend Medius of Larissa. After some heavy drinking, immediately before or after a bath, he was forced into bed due to severe illness. The rumors of his illness circulated with the troops causing them to be more and more anxious. On June 9, the generals decided to let the soldiers see their king alive one last time. They were admitted to his presence one at a time. While the king was too ill to speak, confined himself to move his hand. The day after, Alexander was dead.

The poisoning theory derives from the story held in antiquity by Justin and Curtius. The original story stated that Cassander, son of Antipater, viceroy of Greece, brought the poison to Alexander in Babylon in a mule's hoof, and that Alexander's royal cupbearer, Iollas, brother of Cassander, administered it. Many had powerful motivations for seeing Alexander gone, and were none the worse for it after his death. Deadly agents that could have killed Alexander in one or more doses include hellebore and strychnine. In R. Lane Fox's opinion, the strongest argument against the poison theory is the fact that twelve days had passed between the start of his illness and his death and in the ancient world, such long-acting poisons were probably not available.



However, the warrior culture of Macedon favoured the sword over strychnine, and many ancient historians, like Plutarch and Arrian, maintained that Alexander was not poisoned, but died of natural causes. Instead, it is likely that Alexander died of malaria or typhoid fever, which were rampant in ancient Babylon. Other illnesses could have also been the culprit, including acute pancreatitis or the West Nile virus. Recently, theories have been advanced stating that Alexander may have died from the treatment not the disease. Hellebore, believed to have been widely used as a medicine at the time but deadly in large doses, may have been overused by the impatient king to speed his recovery, with deadly results. Disease-related theories often cite the fact that Alexander's health had fallen to dangerously low levels after years of heavy drinking and suffering several appalling wounds (including one in India that nearly claimed his life), and that it was only a matter of time before one sickness or another finally killed him.

No story is conclusive. Alexander's death has been reinterpreted many times over the centuries, and each generation offers a new take on it. What is certain is that Alexander died of a high fever on June 10 or 11 of 323 BC.

On his death bed, his marshals asked him to whom he bequeathed his kingdom. Since Alexander had no heir (his son Alexander IV would be born after his death), it was a question of vital importance. There is some debate to what Alexander replied. Some believe that Alexander said, "To the strongest!" It should be taken into note however that he might have said, "To Craterus". This is possible because the Greek pronunciation of "the strongest" and "Craterus" is different only by accent. The phrase and name are in fact, separated by only one letter in the ancient Greek language. Most scholars believe that if Alexander did intend to choose one of his generals, his obvious choice would have been Craterus because he was the commander of the largest part of the army (infantry), because he had proven himself to be an excellent strategist, and because he displayed traits of the "ideal" Macedonian. Regardless of his reply, Craterus was eventually assassinated before he could organize a coup with the infantry and Alexander's empire was split into four kingdoms.


Alexander's death has been surrounded by as much controversy as many of the events of his life. Before long, accusations of foul play were being thrown about by his generals at one another, making it incredibly hard for a modern historian to sort out the propaganda and the half-truths from the actual events. No contemporary source can be fully trusted because of the incredible level of self-serving recording, and as a result what truly happened to Alexander the Great may never be known.

Alexander's body was placed in a gold anthropid sarcophagus, which was in turn placed in a second gold casket and covered with a purple robe. Alexander's coffin was placed, together with his armour, in a gold carriage which had a vaulted roof supported by an Ionic peristyle. The decoration of the carriage was very rich and is described in great detail by Diodoros.

According to legend, Alexander was preserved in a clay vessel full of honey (which acts as a preservative) and interred in a glass coffin. According to Aelian (Varia Historia 12.64), Ptolemy stole the body and brought it to Alexandria, where it was on display until Late Antiquity. It was here that Ptolemy IX, one of the last successors of Ptolemy I, replaced Alexander's sarcophagus with a glass one, and melted the original down in order to strike emergency gold issues of his coinage. The citizens of Alexandria were outraged at this and soon after Ptolemy IX was killed. Its current whereabouts are unknown.

The so-called "Alexander Sarcophagus," discovered near Sidon and now in the Istanbul Archaeological Museum, is now generally thought to be that of Abdylonymus, whom Hephaestion appointed as the king of Sidon by Alexander's order. The sarcophagus depicts Alexander and his companions hunting and in battle with the Persians.

Alexander and his exploits were admired by many Romans who wanted to associate themselves with his achievements, although very little is known about Roman-Macedonian diplomatic relations of that time. Julius Caesar wept in Spain at the mere sight of Alexander's statue and Pompey the Great rummaged through the closets of conquered nations for Alexander's 260-year-old cloak, which the Roman general then wore as the costume of greatness. However, in his zeal to honor Alexander, Augustus accidentally broke the nose off the Macedonian's mummified corpse while laying a wreath at the hero's shrine in Alexandria, Egypt. The unbalanced emperor Caligula later took the dead king's armor from that tomb and donned it
for luck. The Macriani, a Roman family that rose to the imperial throne in the 3rd century A.D., always kept images of Alexander on their persons, either stamped into their bracelets and rings or stitched into their garments. Even their dinnerware bore Alexander's face, with the story of the king's life displayed around the rims of special bowls.

In the summer of 1995, during the archaeological work of the season centered on excavating the remains of domestic architecture of early-Roman date, a statue of Alexander was recovered from the structure, which was richly decorated with mosaic and marble pavements and probably was constructed in the 1st century AD and occupied until the 3rd century.