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April 7 - The Huns sack Metz.

June 20 - The Huns and the Ostrogoths facing the Romans and the Visigoths achieve at best a draw in the Battle of Chalons. After the battle, between 10,000 and 20,000 men lie dead on the Catalaunian Fields.

In Italy, refugees flee to swamp areas near modern-day Venice.

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Battle of Vartanantz: Armenian army is defeated by the Persians, and their rebel leader, Saint Vartan, dies. Despite the loss, Armenians consider this battle to have been a moral victory, and its anniversary is a national and religious holiday.

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Sassanid ruler Yazdegerd II's decree abolishes the Sabbath and orders executions of Jewish leaders, including the Exilarch Mar Nuna.

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October 8 - Council of Chalcedon, Ecumenical council of the Christian church. As a result of this council the Oriental Orthodox churches became a separate communion.

Jerusalem becomes a Patriarchate.

Dioscorus of Alexandria is deposed as Patriarch of Antioch.

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Jacob of Serugh - Syriac author

Brigid of Ireland - Irish saint

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Theodoric, king of the Visigoths (killed in battle)