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January 22 - Battle of Ridanieh: The Turkish forces of Selim I defeat the main Mamluk army in Egypt under Touman Bey.

February 3 - Capture of Cairo by the Ottoman Empire; fall of Mamluk Sultanate.

First contact of organized western merchants with China.

August 15 - Portuguese merchant Fernao Pires de Andrade met Chinese officials through an interpreter at Pearl River estuary and landed at Hong Kong.

October 31 - Protestant Reformation: Martin Luther posts his 95 Theses on the door of the Wittenberg Castle Church.

Grand Prince Vasili III of Muscovy conquers Riazan.

Selim I, Sultan of the Ottoman Empire, conquers Palestine and Egypt and declares himself Caliph.

A third outbreak of the sweating sickness in England hits Oxford and Cambridge.

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Jacques Pelletier du Mans, French mathematician (died 1582)

Henry Howard, Earl of Surrey, English aristocrat (died 1547)

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March 26 - Heinrich Isaac, Flemish composer (born c. 1450)

October 31 - Fra Bartolommeo, Italian artist (born 1472)

November 8 - Francisco Cardinal Jiménez de Cisneros, Spanish Cardinal and statesman (born 1436)

Francisco Hernández de Córdoba, Spanish conquistador

Luca Pacioli, Italian mathematician (born 1445)

Francesco Raibolini, Italian painter (born c. 1450)

Dyveke Sigbritsdatter, mistress of Christian II of Denmark

Gaspar van Weerbeke, Dutch composer (born 1445)

Badi' al-Zaman, Timurid ruler of Herat