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June - Invasion of Persia by Sultan Selim I of the Ottoman Empire.

August 23 - Battle of Chaldiran. Selim I crushes the Persian army of Shah Ismail I.

September 5 - Selim captures the Persian capital of Tabriz without encountering any resistance, but is unable to hold it.

September 13 - September 14 - Battle of Marignano - The army of Francis I of France defeats the Swiss, thanks to the timely arrival of a Venetian army. Francis restores French control of Milan.

November 15 - Thomas Cardinal Wolsey invested as a Cardinal.

December 24 - Thomas Wolsey is named the English Lord Chancellor.

Sweden declared independence.

Ottoman Empire conquers Kurdistan.

The Manchester Grammar School founded.

Conquistador Diego Velázquez de Cuéllar founded Havana, Cuba.

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1515 in art

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March 28 - Saint Teresa of Avila, Spanish Carmelite nun and poet (died 1582)

July 21 - Philip Neri, Italian churchman (died 1595)

September 8 - Alfonso Salmeron, Spanish Jesuit biblical scholar (died 1585)

September 22 - Anne of Cleves, fourth queen of Henry VIII of England (died 1557)

October 4 - Lucas Cranach the Younger, German painter (died 1586)

October 8 - Margaret Douglas, Countess of Lennox (died 1578)

November 22 - Mary of Guise, queen of James V of Scotland and regent of Scotland (died 1560)

Cristobal Acosta, Portuguese doctor and natural historian (died 1580)

Sebastian Castellio, rector of the College of Geneva (died 1563)

Valerius Cordus, German physician (died 1544)

Sebastian Franck, German freethinker (died 1543)

Pierre de la Ramée, French humanist scholar (died 1572)

Mikolaj Czarny Radziwill, Polish magnate (died 1565)

Cypriano de Rore, Flemish composer and teacher (died 1565)

Thomas Seckford, Master of Requests for Elizabeth I of England (died 1587)

John Sheppard, English composer and organist (died 1560)

Francisco de Toledo, Count of Oropesa, (died 1584)

Johann Weyer, German physician (died 1588)

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January 1 - King Louis XII of France (born 1462)

January 15 - Diebold Schilling the Younger, Swiss chronicler

February 6 - Aldus Manutius, Venetian printer (born c1449)

November 5 - Mariotto Albertinelli, Italian painter (born 1474)

December 2 - Gonzalo Fernández de Córdoba, Spanish general and statesman (b. 1453)

December 16 - Afonso de Albuquerque, Portuguese naval general (born 1453)

Antoine Brumel, Flemish composer (born 1460)

Nezahualpilli, Aztec philosopher (born 1464)

Alonso de Ojeda, Spanish conquistador (born 1466)