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February 2 - Battle of Diu took place near Diu, India.

April 22 - Henry VIII becomes King of England on the death of his father, Henry VII.

April 27 - Pope Julius II places Venice under interdict and excommunication for refusing to cede part of Romagna under Papal control

May 14 - Battle of Agnadello - French forces defeat the Venetians.

June 11 - Henry VIII of England marries Catherine of Aragon

June 24 - King Henry VIII of England's and Queen consort's Catherine of Aragon coronation ceremony.

Erasmus publishes his most famous work, In Praise of Folly.

Royal Dano-Norwegian Navy founded.

St Paul's School founded.

Queen Elizabeth's Grammar School founded.

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January 25 - Giovanni Morone, Italian cardinal (d. 1580)

July 10 - John Calvin, French religious reformer (died 1564)

August 3 - Étienne Dolet, French scholar and printer (died 1546)

Nicholas Bacon, English politician (died 1579)

Tommaso Campanella, Italian theologian, philosopher and poet (died 1639)

John Erskine of Dun, Scottish religious reformer (died 1591)

John of Leiden, Dutch Anabaptist leader (died 1536)

Stanislaw Odrowaz, Polish noble (died 1545)

Gonzalo Jimenez de Quesada, lawyer (died 1579)

Edward Seymour, 1st Duke of Somerset, Lord Protector of England (died 1552)

Bernardino Telesio, Italian philosopher and natural scientist (died 1588)

Kamran Mirza, Mughal prince (died 1557)

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April 21 - King Henry VII of England (born 1457)

May 10 - Caterina Sforza, countess of Forli (born 1463)

June 29 - Margaret Beaufort, mother of Henry VII of England (born 1443)