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April 7 - Charles University is founded in Prague.

June 24 - Black Death outbreak in full swing in Melcombe Regis (modern-day Weymouth, Dorset in England)

July 6 - Papal bull of Pope Clement VI protecting Jews against popular aggressivity during the Black Death epidemic.

Beginning of Black Death epidemic in central and western Europe

End of the reign of Emperor Komyo of Japan, second of the Northern Ashikaga Pretenders

Start of the reign of Emperor Suko of Japan, third of the Northern Ashikaga Pretenders

May - Black Death reaches England

Edward III of England creates the first English order of chivalry, the Order of the Garter

Pskov gains independence from the Novgorod Republic with the treaty of Bolotovo; Pskov Republic formed.

Black Death in Cairo.

Estimation: Hangzhou in Mongolian China becomes the largest city of the world, taking the lead from Cairo, capital of Mamluk Egypt.*

Truce between England and France until 1350.

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John Fitzalan, 1st Lord Arundel (died 1379)

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February 2 - Narymunt, Prince of Pinsk

December 2 - Emperor Hanazono, Emperor of Japan (born 1297)

Laura, beloved of Petrarch (born 1310)

John de Stratford, Archbishop of Canterbury

Ambrogio Lorenzetti, Sienese painter (born 1290)

Pietro Lorenzetti, Sienese painter (born 1280)

Andrea Pisano, Italian sculptor and architect (born 1270)