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Oxygen (O₂, in its molecular form)

O2 plc, a telecommunications company.

O-2 Skymaster

O2, an album released by boy band O-Town in 2002

O2, a 2000 album by hard rockers FireHouse

The O2 line of extreme sports games by Activision, a video game publisher

The 02 Raffles Institute Scout Group - see The Singapore Scout Association

O2 star, a subclass of O-class stars

Magnavox Odyssey², a games console

Oceanic Airlines (Guinea) IATA airline designator

O2Jam, a Korean electronic rhythm game

SGI O2, a workstation computer

The O₂, a large dome-shaped building in London

"O2", a song by Sleater-Kinney from their 2002 album One Beat