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O'Neill (brand), a wetsuit and surf clothing manufacturer

O'Neill class battleship, fictional spacecraft in the television show Stargate SG-1

O'Neill cylinder, a space habitat design, proposed by Gerard O'Neill

Baron O'Neill, title in the Peerage of the United Kingdom

Earl O'Neill, title in the Peerage of Ireland

P. O'Neill, a pseudonym used in statements of the Provisional Irish Republican Army

Sandler O'Neill and Partners, New York City-based investment banking firm that lost 67 employees in the 9/11-attacks

Tip O'Neill Award, Canadian Baseball award, named after Tip O'Neill (baseball player)

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Conn O'Neill, 1st Earl of Tyrone (c. 1480–1559)

Felim O'Neill of Kinard (also known as Phelim O'Neill, died 1652), leader of the Irish Rebellion of 1641

Hugh O'Neill, 3rd Earl of Tyrone (c. 1540–1616), The O'Neill-rebel leader in the Nine Years War

Hugh Dubh O'Neill (1611–1660), Irish soldier in the Irish Confederate Wars

Hugh McShane O'Neill (17th century), Irish rebel, Lord, and highwayman

Owen Roe O'Neill (c. 1590–1649), leader of the Ulster Irish army during the Irish Confederate Wars

Patrick O'Neill (17th century), Irish soldier and the first Count of Tyrone

Phelim Caoch O'Neill (16th century), prince of the Cenél nEógan

Shane O'Neill (c. 1530–1567), Irish chief of the O'Neill clan of Ulster

Tirlough Brassileagh O'Neill (16th century), son of Phelim Caoch O'Neill

Turlough Luineach O'Neill (c. 1530–1595), earl of Clan-connell, King of Tyrone

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Ana María O'Neill (1894–1981), Puerto Rico women's rights activist

B.F. O'Neal, Jr. (1922–2004), Louisiana businessman Republican politician

C. William O'Neill (1916–1978), Ohio Republican politician

Charles O'Neill (1821–1893), United States Congressman

Charles Duncan O'Neale (1879–1936), Barbados politician and physician

Clare O'Neil, Australian politician, mayor and student

Dave O'Neal (born 1937), American politician, former Lieutenant Governor of Illinois

Eamonn O'Neill (Irish politician) (died 1954), Irish politician

Emmet O'Neal (1853–1922), American Democratic politician who was Governor of Alabama

Hugh O'Neil (born 1936), Canadian politician

Hugh O'Neill, 1st Baron Rathcavan (1883–1982), Northern Irish politician

Ivan O'Neal, Vincentian political leader

James O'Neill (politician) (19th century), New Zealand politician

Margaret O'Neill Eaton (better known as Peggy O'Neill, 1799–1879), central person in the Petticoat Affair (1983 US sex scandal)

Martin O'Neill, Baron O'Neill of Clackmannan (born 1945), Scottish politician

Michael O'Neill (politician) (born 1910), Irish politician in the United Kingdom

Mike O'Neal (born 1951), Kansas Republican politician

Mildred O'Neill (1914–2003), wife of Tip O'Neill

Onora Sylvia O'Neill, Baroness O'Neill of Bengarve (born 1941), British House of Lords member, philosopher, life peer

Paul O'Neill (born 1935), 72nd United States Secretary of the Treasury

Ralph T. O'Neal, British Virgin Islands politician

Rose O'Neal Greenhow (1817–1864), Confederate spy

Terence O'Neill (1914–1990), 4th Prime Minister of Northern Ireland

Thomas O'Neill (journalist), American journalist and Nixon opponent

Thomas P. O'Neill III, leader of the Boston public relations and government affairs firm O'Neill and Associates, son of Tip O'Neill

Tip O'Neill (Thomas Phillip O'Neill, 1912–1994), former US Congressman and Speaker of the House of Representatives

William O'Neill (Connecticut politician) (born 1930), American political figure

Yvonne O'Neill (born 1936), Canadian politician

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Alexandre O'Neill (1924–1986), Portuguese poet of Irish origin

Alexander O'Neal (born 1953), American musician

Andrew O'Neill (born 1979), British comedian

Barbara O'Neil (1910–1980), American actress, Oscar nominated

Brittany O'Neil (born 1971), British porno actress

Carol O'Neal (born 1948), American model and Playboy magazine's Playmate of the Month in July 1972

Charles O'Neal (born 1904), American film and televion screenwriter

Colette O'Neil, British television actress

Con O'Neill, British theatre actor

Dan O'Neill (born 1942), American underground cartoonist

Daria O'Neill (born 1971), American radio and television personality

Dennis O'Neil, comic book writer and editor

Dennis Joseph O'Neil (born 1981), South Korean actor

Ed O'Neill (born 1946), American actor

Eliza O'Neill (1791–1872), Irish actress

Elizabeth O'Neill Verner (1883–1979), American artist

Ella O'Neill (19th century), mother of Eugene O'Neill and wife of James O'Neill

Eugene O'Neill (1888–1953), American playwright, Nobel and Pulitzer Prize winner

Francis O'Neill (1848–1936), Irish traditional music collector

Frank O'Neal, American cartoonist

Griffin O'Neal (born 1964), American actor

Henry O'Neill (1891–1961), film actor

Henry Nelson O'Neil (1817–1880), British historical genre painter and minor Victorian writer

James O'Neill (actor) (1849–1920), Irish-American actor

Jamie O'Neal (born Jamie Murphy, 1968), Australian country singer and songwriter

Jerry O'Neill (born 1968), American born artist and writer

Jamie O'Neill (born 1962), Irish author

John J. O'Neill, journalist, 1937 Pulitzer Prize winner

John O'Neill (editor), science fiction magazine editor

Johnny O'Neal, American jazz pianist

Jennifer O'Neill (born 1948), American actress and author

Karen O'Neil Ganci (born 1974), American portrait artist and Big Brother contestant

Kevin O'Neill (comics) (born 1953), British comics illustrator

Linda O'Neil (1974), American model and actress

Maire O'Neill (born Mary Allgood, 1885–1952), Irish stage and film actress

Mary Devenport O'Neill (1879–1967), Irish poet and dramatist

Melissa O'Neil (born 1988), Canadian singer, winner of the third season of Canadian Idol

Michael O'Neill (actor), American actor

Mike O'Neill (musician), Canadian singer-songwriter

Moira O'Neill (pseudonym of Agnes Shakespeare Higginson, 1864–1955), Irish-Canadian poet

Nance O'Neil (1874–1965), American stage and silent movie actress

O'Neil De Noux (born 1950), American writer of short stories and novels

Oona O'Neill (1925–1991), daughter of Eugene O'Neill

Pat O'Neill (born 1939), American experimental film-maker

Patrice Oneal (born 1969), African-American comedian

Patrick O'Neal (1927–1994), American television, stage, and film actor

Paul O'Neill (author) (born 1928), Canadian historian, writer and producer

Peggy O'Neal, voice actress

Reagan O'Neal, pseudonym of James Oliver Rigney, Jr (born 1948), American writer

Ron O'Neal (1937–2004, American actor, director and screenwriter

Rose O'Neill (1874–1944), American illustrator and writer

Ryan O'Neal (born 1941), American actor

Séamus Ó Néill (1910–1986), versatile Irish writer

Simon O'Neill (born 1971), International opera singer.

Tatum O'Neal (born 1963), American actress

Terry O'Neill (karateka) (born 1948), British martial artist and actor

Terry O'Neill (photographer) (born 1938), British fashion and celebrity photographer

Tony O'Neill, New York based musician and author

Ty O'Neal (born 1978), American actor

Ward O'Neill (born 1951), Australian illustrator, caricaturist and cartoonist

Wil O'Neal, American technology journalist

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Buck O'Neil (John Jordan O'Neil, born 1911), American baseball player and manager in the Negro league baseball

Chris O'Neil (born 1956), Australian female tennis player, winner of the 1978 Australian Open.

Deltha O'Neal (born 1977), American football player

Eamon O'Neill, Irish professional wrestler

Ed O'Neil (football), (born 1952), NFL Europe coach and former NFL American football player

Fabian O'Neill (born 1973), Uruguayan football (soccer) midfielder

Gary O'Neil (born 1983), English football (soccer) player

Jack O'Neill (baseball) (1873–1935), Irish-American baseball player

Jeff O'Neill (born 1976) Canadian NHL hockey player

Jermaine O'Neal (born 1978), American NBA basketball player

Jerry O'Neil (1956), American NASCAR auto racer

John O'Neill (rugby league footballer) (1943–1999), Australian rugby player

John O'Neill (sport administrator), Australian sporting administrator

Jonjo O'Neill (born 1953), Irish jockey

Keith O'Neil (born 1980), American football linebacker

Keith O'Neill (footballer), Irish football player

Kevin O'Neill (basketball) (born 1957), American basketball coach

Kevin O'Neill (footballer), Scottish football (soccer) player

Kitty O'Neil (born 1946), American stuntwoman and racer

Leslie O'Neal (born 1964), American Football player

Mark O'Neill (born 1975), Australian rugby league player

Martin O'Neill (born 1952), Northern Irish football (soccer) player and manager

Mike O'Neill (baseball player) (1877–1959), Irish-American baseball player

Nathan O'Neill (born 1974), Australian professional cyclist, Commonwealth Games gold medallist

Norm O'Neill (born 1937), Australian cricket player

O'Neil Bell (born 1974), Jamaican cruiserweight boxing champion

O'Neil Longson, American professional poker player

Paul O'Neill (baseball player) (born 1963), American Major League baseball player

Paul O'Neill (racecar driver), Irish-British racecar driver

Seán O'Neill, Northern Irish Gaelic football player

Shaquille O'Neal (born 1972), American basketball player

Stephen O'Neill, Irish Gaelic footballer

Steve O'Neill (1891–1962), American baseball player, manager and coach

Susan O'Neill (born 1973), Australian swimmer, Olympic gold medallist

Tip O'Neill (baseball player) (1858–1915), Canadian baseball player

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Edward Asbury O'Neal (1818–1890), American Confederate general during the American Civil War

Gerard O'Neill (1927–1992), American physicist and space pioneer

Jack O'Neill (businessman), founder of the wetsuit manufacturing company O'Neill

James O'Neil Mayne (1861–1938), University of Queensland donator

Jasmine O'Neill, mute autistic woman, autistic rights activists

John O'Neill (VC) (1897–1942), Scottish soldier, recipient of the Victoria Cross

John O'Neill (Vietnam veteran) (born 1946), Vietnam War veteran, lawyer and spokesman for Swift Vets and POWs for Truth

John P. O'Neill (1952–2001), American anti-terrorism expert, died in the 9/11-attacks

Merlin O'Neill (1898–1981), seventh Commandant of the United States Coast Guard

O'Neil Ford (1905–1982), Texas architect

Michael O'Neill (educator), American educator

Pete O'Neal (born 1940), American Black Panther Party member

Stan O'Neal, American manager

Pauline O'Neill, first president of Saint Mary's College in Notre Dame, Indiana

Robin O'Neil, British Holocaust researcher

Robin O'Neill, (born 1958) American Software Engineer

Tom O'Neill, chairman and CEO of Parsons Brinckerhoff

William O'Neil (born 1933), American entrepreneur, stockbroker and writer

William O'Neill (Ohio jurist), American jurist and judge

William C. O'Neil, descendant of Davy Crockett (Through the Carmack family) and William F. O'Neil

William F. O'Neil, Founder of General Tire in 1915

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April O'Neil, character in Teenage Mutant Ninja Turtles

Connor O'Neill, character in the Australian soap opera Neighbours

Derek O'Neil, detective in the comic The Gasman

Jack O'Neill, character in the Stargate film and television series

Young Jack O'Neill, character in the Stargate SG-1 television series, clone of Jack O'Neill

Timothy O'Neill, animated character in MTV's animated series Daria

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O'Neill, Nebraska, USA

O'Neil, Florida, USA

O'Neill Collegiate and Vocational Institute, school in Oshawa, Ontario

O'Neill Hall (University of Notre Dame), men's residence hall at the University of Notre Dame in Notre Dame, Indiana

O’Neill House Office Building, former Congressional Office Building in Washington D.C., named after Tip O'Neill

Eugene O'Neill Theatre, a Broadway Theatre named after Eugene O'Neill

Eugene O'Neill National Historic Site, former home of Eugene O'Neill

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